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学者姓名：王嗣岑
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Abstract ：
Glioma is the most common primary craniocerebral malignant tumor, arising from the canceration of glial cells in the brain and spinal cord. The quality of life and prognosis of patients with this disease are still poor. Doxorubicin (DOX) is one of the most traditional and economical chemotherapeutic drugs for the treatment of glioma, but its toxic effect on normal cells and the resistance of tumor cells to DOX make the application of DOX in the treatment of glioma gradually less effective. To solve this problem, we co-encapsulated DOX and endogenous tumor suppressor miR-125b into nanoparticles (NPs) by nanoprecipitation methods, and passively targeted them into glioma cells. In vitro experiments show that miR-125b and DOX can be effectively encapsulated into nanoparticles with different ratios, and by targeting YES proto-oncogene 1 (YES1), they can affect the adenosine 5 '-monophosphate (AMP)-activated protein kinase (AMPK)/p53 pathway and induce brain glioma cell apoptosis. They can also affect the DNA damage repair process and inhibit cell proliferation. The obtained data suggest that co-delivery of DOX and miR-125b could achieve synergistic effects on tumor suppression. Nanosystem-based co-delivery of tumor suppressive miRNAs and chemotherapeutic agents may be a promising combined therapeutic strategy for enhanced anti-tumor therapy.
Keyword ：
DNA damage glioma miR-125b nanoparticles (NPs)
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| GB/T 7714 | Wang, Lin , Pan, Tingting , Wang, Yan et al. Effect of Nanoparticles of DOX and miR-125b on DNA Damage Repair in Glioma U251 Cells and Underlying Mechanisms [J]. | MOLECULES , 2022 , 27 (19) . |
| MLA | Wang, Lin et al. "Effect of Nanoparticles of DOX and miR-125b on DNA Damage Repair in Glioma U251 Cells and Underlying Mechanisms" . | MOLECULES 27 . 19 (2022) . |
| APA | Wang, Lin , Pan, Tingting , Wang, Yan , Yu, Jiewen , Qu, Peiyi , Chen, Yue et al. Effect of Nanoparticles of DOX and miR-125b on DNA Damage Repair in Glioma U251 Cells and Underlying Mechanisms . | MOLECULES , 2022 , 27 (19) . |
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Abstract ：
In this study, ecofriendly and economic carboxy-terminated plant fibers (PFs) were used as adsorbents for the effective in-syringe solid phase extraction (IS-SPE) of fluoroquinolone (FQ) residues from water. Based on the thermal esterification and etherification reaction of cellulose hydroxy with citric acid (CA) and sodium chloroacetate in aqueous solutions, carboxy groups grafted onto cotton, cattail, and corncob fibers were fabricated. Compared with carboxy-terminated corncob and cotton, CA-modified cattail with more carboxy groups showed excellent adsorption capacity for FQs. The modified cattail fibers were reproducible and reusable with relative standard deviations of 3.2%-4.2% within 10 cycles of adsorptiondesorption. A good extraction efficiency of 71.3%-80.9% was achieved after optimizing the extraction condition. Based on carboxylated cattail, IS-SPE coupled with ultra-performance liquid chromatography with a photodiode array detector was conducted to analyze FQs in environmental water samples. High sensitivity with limit of detections of 0.08-0.25 mg/L and good accuracy with recoveries of 83.8%-111.7% were obtained. Overall, the simple and environment-friendly modified waste PFs have potential applications in the effective extraction and detection of FQs in natural waters. (c) 2022 The Authors. Published by Elsevier B.V. on behalf of Xi'an Jiaotong University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keyword ：
Carboxylation modification Cattail fiber Fluoroquinolones In -syringe solid phase extraction
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| GB/T 7714 | Zhang, Nan , Gao, Yan , Sheng, Kangjia et al. Effective extraction of fluoroquinolones from water using facile modified plant fibers [J]. | JOURNAL OF PHARMACEUTICAL ANALYSIS , 2022 , 12 (5) : 791-800 . |
| MLA | Zhang, Nan et al. "Effective extraction of fluoroquinolones from water using facile modified plant fibers" . | JOURNAL OF PHARMACEUTICAL ANALYSIS 12 . 5 (2022) : 791-800 . |
| APA | Zhang, Nan , Gao, Yan , Sheng, Kangjia , Jing, Wanghui , Xu, Xianliang , Bao, Tao et al. Effective extraction of fluoroquinolones from water using facile modified plant fibers . | JOURNAL OF PHARMACEUTICAL ANALYSIS , 2022 , 12 (5) , 791-800 . |
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Abstract ：
Sample preparation is an indispensable part of detection of complex samples in pharmaceutical analysis. Solid -phase microextraction (SPME) has obtained a lot of attention due to its advantages of time saving, less solvent and easily automation. A variety of functional materials are used as sorbents in SPME to carry out selective and high extraction. This review centers around the recent applications of organic molecule-based framework porous materials, such as metal organic frameworks (MOFs) and covalent organic frameworks (COFs), as SPME coating materials mainly focus on pharmaceutical analysis in food, environment, and biological samples. Four repre-sentative extraction devices are introduced, including on-fiber SPME, in-tube SPME, thin film SPME, stir bar SPME. The application prospect of other organic porous materials as sorbents for pharmaceutical analysis are also discussed, such as hyper crosslinked polymers (HCPs) and conjugated microporous polymers (CMPs). The progresses and discusses are provided to offer references for further research focusing on application and development of organic molecule-based framework porous materials in the field of SPME.
Keyword ：
Covalent organic frameworks Metal organic frameworks Pharmaceutical analysis Solid -phase microextraction
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| GB/T 7714 | Gao, Yan , Sheng, Kangjia , Bao, Tao et al. Recent applications of organic molecule-based framework porous materials in solid-phase microextraction for pharmaceutical analysis [J]. | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS , 2022 , 221 . |
| MLA | Gao, Yan et al. "Recent applications of organic molecule-based framework porous materials in solid-phase microextraction for pharmaceutical analysis" . | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 221 (2022) . |
| APA | Gao, Yan , Sheng, Kangjia , Bao, Tao , Wang, Sicen . Recent applications of organic molecule-based framework porous materials in solid-phase microextraction for pharmaceutical analysis . | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS , 2022 , 221 . |
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In this study, we report the adsorption removal of indomethacin sodium (IDM) by the mixed-linker Materials of Institute Lavoisier (MIL)-101(Cr)s. The MIL-101(Cr)s were synthesized by controlling the ratios of 1,4-benzene dicarboxylic acid (H2BDC) and 2-amino-1,4-benzene dicarboxylic acid (NH2-H2BDC). Then their adsorption performances toward IDM were investigated. Due to the increase in specific surface area and the contribution of enhanced multiple action mechanisms, MIL-101(20) was proved to have the optimal IDM absorption among all the mixed-ligand MIL-101(Cr)s. The adsorption kinetic data was found to accord with the pseudo-second-order kinetic model, and the rate constant (k(2)) was calculated as 0.0059 g mg(-1) min(-1). The selected MIL-101(20) exhibited the maximum IDM adsorption capacity of approximately 641 mg g(-1) (318 K), calculated from the Langmuir linear plots. The simulation results of the thermodynamic model suggest that the adsorption could be a spontaneous, endothermic process with increasing randomness. The adsorption mechanism analysis indicates that the synergistic effects of electrostatic interaction, hydrogen bond interaction, and pi-pi stacking could be responsible for efficient IDM adsorption. In addition, the adsorbent also presented good reproducibility over six successive adsorption/desorption cycles. Therefore, the mixed-ligand MIL-101(Cr) could be recommended as a promising adsorbent for the preferential removal of IDM from polluted wastewater.
Keyword ：
Adsorption Indomethacin sodium (IDM) MIL-101(Cr) Mixed-ligand
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| GB/T 7714 | Zhang, Xiaxi , Wei, Fen , Bao, Tao et al. Target adsorption of indomethacin sodium from aqueous solutions using mixed-ligand MIL-101(Cr) [J]. | JOURNAL OF SOLID STATE CHEMISTRY , 2022 , 311 . |
| MLA | Zhang, Xiaxi et al. "Target adsorption of indomethacin sodium from aqueous solutions using mixed-ligand MIL-101(Cr)" . | JOURNAL OF SOLID STATE CHEMISTRY 311 (2022) . |
| APA | Zhang, Xiaxi , Wei, Fen , Bao, Tao , Wang, Sicen . Target adsorption of indomethacin sodium from aqueous solutions using mixed-ligand MIL-101(Cr) . | JOURNAL OF SOLID STATE CHEMISTRY , 2022 , 311 . |
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Abstract ：
Herein, corncob waste was used as a scaffold for the fabrication of effective adsorbents. Porphyrinic zirconium metal-organic frameworks (MOFs) PCN-223 and PCN-224 constructed by different numbers of Zr6 cluster nodes were grown on the surface of the corncob. Fe (SIC) ions were implanted in the porphyrin ring by post-synthesis modification. The results showed that the extraction capacity of diuretics on PCN-224@corncob containing suitable pore size was larger than that of PCN-223@corncob. The adsorption of diuretics was further enhanced because of the electrostatic effect caused by implantation of Fe (SIC) ions. PCN-224-Fe@corncob was recyclable and selective for the extraction of furosemide (Fur) and bumetanide (Bum). Coupled in-syringe solid phase extraction (IS-SPE) with ultra-performance liquid chromatography (UPLC), an efficient, sensitive, and stable method was established. With a sensitivity between 0.6 and 1.0 mu g/L and a recovery between 83.2% and 119.2%, it is used for the analysis of trace amounts of Fur and Bum in weight loss products and environmental water. The functionalized corncob has potential application for the adsorption of diuretics, and the metal ions implantation in MOFs provides a promising strategy for enhancing extraction capacity.
Keyword ：
Corncob waste recycling Diuretics In-syringe solid phase extraction PCN-224-Fe Post-synthesis modification
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| GB/T 7714 | Zhang, Nan , Gao, Yan , Sheng, Kangjia et al. Ferric iron loaded porphyrinic zirconium MOFs on corncob for the enhancement of diuretics extraction [J]. | CHEMOSPHERE , 2022 , 301 . |
| MLA | Zhang, Nan et al. "Ferric iron loaded porphyrinic zirconium MOFs on corncob for the enhancement of diuretics extraction" . | CHEMOSPHERE 301 (2022) . |
| APA | Zhang, Nan , Gao, Yan , Sheng, Kangjia , Xu, Xianliang , Jing, Wanghui , Bao, Tao et al. Ferric iron loaded porphyrinic zirconium MOFs on corncob for the enhancement of diuretics extraction . | CHEMOSPHERE , 2022 , 301 . |
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Abstract ：
MOF@COF composite was fabricated for greater adsorption capacity through the utilization of corncob, which is a natural, sustainable, and cellulose-rich resource. An in-situ growth strategy was implemented to graft UiO-66-NH2 on carboxyl-terminal corncob induced by the thermal esterification of critic acid. Subsequently, corncob@UiO-66-NH2@TpBD was constructed through the Schiff base reaction between 2,4,6-triformylphloroglucinol (Tp) and UiO-66-NH2 as well as benzidine (BD). The ratio of UiO-66-NH2 and TpBD was optimized to be 5:3 for enhancing adsorption capacity. Based on the pi-pi, hydrogen bonding, and -SO2-Zr-O-coordination effect, sulphonamides (SAs) were chosen to investigate the adsorption capacity of adsorbent using an in-syringe solid phase extraction (IS-SPE) method. The binding energy calculated using density functional theory (DFT) reached-37.45 Kcal/mol, which indicated the strong interactions between SAs and corncob@UiO-66-NH2@TpBD. Combined with ultra-performance liquid chromatography (UPLC), a high sensitivity was obtained with low detection of 0.10 mu g/L. The prepared corncob@UiO-66-NH2@TpBD exhibited good reproducibility within relative standard deviations (RSDs) 3.1%-3.4% in intra-batch and 4.3%-8.4% in inter-batch. Moreover, the extraction capacity of adsorbent was not decreased in 20 recycles adsorption-desorption within RSDs 3.8%-8.5%. With features of permanent porosity, multiple active sites, and good renewability, corncob@UiO-66-NH2@TpBD shows great potential towards industrial applications in the field of adsorption.
Keyword ：
Corncob In-situ growth Sulfonamides TpBD UiO-66-NH2
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| GB/T 7714 | Zhang, Nan , Bao, Tao , Gao, Yan et al. Growth of MOF@COF on corncob as effective adsorbent for enhancing adsorption of sulfonamides and its mechanism [J]. | APPLIED SURFACE SCIENCE , 2022 , 580 . |
| MLA | Zhang, Nan et al. "Growth of MOF@COF on corncob as effective adsorbent for enhancing adsorption of sulfonamides and its mechanism" . | APPLIED SURFACE SCIENCE 580 (2022) . |
| APA | Zhang, Nan , Bao, Tao , Gao, Yan , Xu, Xianliang , Wang, Sicen . Growth of MOF@COF on corncob as effective adsorbent for enhancing adsorption of sulfonamides and its mechanism . | APPLIED SURFACE SCIENCE , 2022 , 580 . |
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Natural products and their derivatives are a rich source for drug discovery. Meanwhile, cell membrane has emerged as an effective tool to screen the active compounds from natural products. Recently, the cell membrane-coated technology has attracted increasing attention due to its unique biointerfacing abilities. This review focuses on the recent technological advances (2017-2021) in developing cell membrane coated technologies as potential platforms for drug discovery from natural products. Furthermore, the molecular basis of membrane proteins and membrane lipids as drug targets are described. Particularly, four major strategies including cell membrane chromatography and cell membrane-coated magnetic materials are highlighted. Additionally, different functionalization methods for a better screening effect are discussed. Finally, the prospective in terms of subcellular membrane coating, novel coupled technology and stability improvement for high performance exploration are proposed. This review will provide deeper insights into the advanced design and application research of cell membrane-coated technology for drug discovery. (c) 2022 Elsevier B.V. All rights reserved.
Keyword ：
Cell membrane-coated technology Cell membrane precise engineering strategy Drug discovery Magnetic nanoparticles Natural products Surface functionalization strategy
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| GB/T 7714 | Bu, Yusi , Hu, Qi , Bao, Tao et al. Recent advances in cell membrane-coated technology for drug discovery from natural products [J]. | TRAC-TRENDS IN ANALYTICAL CHEMISTRY , 2022 , 151 . |
| MLA | Bu, Yusi et al. "Recent advances in cell membrane-coated technology for drug discovery from natural products" . | TRAC-TRENDS IN ANALYTICAL CHEMISTRY 151 (2022) . |
| APA | Bu, Yusi , Hu, Qi , Bao, Tao , Xie, Xiaoyu , Wang, Sicen . Recent advances in cell membrane-coated technology for drug discovery from natural products . | TRAC-TRENDS IN ANALYTICAL CHEMISTRY , 2022 , 151 . |
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Abstract ：
Background Fingerprint analysis and simultaneous multi-components determination are crucial for the holistic quality control of traditional Chinese medicines (TCMs). Yet, reference standards (RS) are often commercially unavailable and with other shortages, which severely impede the application of these technologies. Methods A digital reference standard (DRS) strategy and the corresponding software called DRS analyzer, which supports chromatographic algorithms, spectrum algorithms, and the combination of these algorithms, was developed. The extensive function also enabled the DRS analyzer to recommend the chromatographic column based on big data. Results Various quality control methods of fingerprints of 11 compounds in polyphenolic acid extract of Salvia miltiorrhiza (S. miltiorrhiza) were developed based on DRS analyzer, involving relative retention time (RRT) method, linear calibration using two reference substances (LCTRS) technique, RRT combined with Photon Diode Array (PDA) method, LCTRS combined with PDA method. Additionally, the column database of samples was established. Finally, our data demonstrated that the DRS analyzer could accurately identify 11 compounds of the samples, using only one or two physical RSs. Conclusions The DRS strategy is an automated, intelligent, objective, accurate, eco-friendly, universal, sharing, and promising method for overall quality control of TCMs that requires the usage of fewer RSs.
Keyword ：
digital reference standard (DRS) Fingerprints Linear calibration using two reference substances (LCTRS) Relative retention time (RRT) Substitute reference standards
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| GB/T 7714 | Wang, Qingjun , Yu, Xinlan , Sun, Lei et al. Fingerprint analysis of phenolic acid extract of Salvia miltiorrhiza by digital reference standard analyzer with one or two reference standards [J]. | CHINESE MEDICINE , 2021 , 16 (1) . |
| MLA | Wang, Qingjun et al. "Fingerprint analysis of phenolic acid extract of Salvia miltiorrhiza by digital reference standard analyzer with one or two reference standards" . | CHINESE MEDICINE 16 . 1 (2021) . |
| APA | Wang, Qingjun , Yu, Xinlan , Sun, Lei , Tian, Runtao , He, Huaizhen , Wang, Sicen et al. Fingerprint analysis of phenolic acid extract of Salvia miltiorrhiza by digital reference standard analyzer with one or two reference standards . | CHINESE MEDICINE , 2021 , 16 (1) . |
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Abstract ：
The common elution process of molecularly imprinted polymers (MIPs) is carried out in an acidic medium, which greatly affects the stability and reusability of synthetic MIPs, especially for magnetic MIPs. In this study, we fabricated an acid-resistant imprinted layer formed by phase-transitioned lysozyme on magnetic nanomaterials for selective extraction of chlorogenic acid in Honeysuckle, which often coexists with structural analogs. The newly designed acid-resistant imprinted layer can not only protect the internal magnetic core from denudation and dissolution, but also maintain the integrity of the imprinted layer during the elution process. The resultant magnetic MIPs exhibited good stability with no change on morphology after the repeatedly eluting process, and satisfactory reusability that can be used at least ten adsorption-desorption cycles with almost no decrease for adsorption capacity. In addition, the resultant materials possess satisfactory magnetism, uniform morphology with typical core-shell structure, stable crystallization, and good adsorption performance showing on high adsorption amount (10.82 mg g(-1)), fast kinetic equilibrium time (as short as 30 min), and satisfactory selectivity (IF = 2.85, SC > 1.5). At last, the obtained magnetic MIPs as adsorbents coupled with HPLC were successfully used to selective extract CGA in Honeysuckle samples with the high recoveries in the range of 92.0-104.4%, and the contents of CGA in Honeysuckle samples from the different origin are calculated in the range of 0.98%-1.24%. (C) 2021 Elsevier B.V. All rights reserved.
Keyword ：
Acid resistance Chlorogenic acid Fe3O4-Cu NPs Phase-transitioned lysozyme Surface imprinting
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| GB/T 7714 | Gao, Yuan , Tang, Yuhai , Gao, Luyao et al. Fabrication of acid-resistant imprinted layer on magnetic nanomaterials for selective extraction of chlorogenic acid in Honeysuckle [J]. | ANALYTICA CHIMICA ACTA , 2021 , 1161 . |
| MLA | Gao, Yuan et al. "Fabrication of acid-resistant imprinted layer on magnetic nanomaterials for selective extraction of chlorogenic acid in Honeysuckle" . | ANALYTICA CHIMICA ACTA 1161 (2021) . |
| APA | Gao, Yuan , Tang, Yuhai , Gao, Luyao , Niu, Yingying , Gao, Ruixia , Chen, Xiaoyi et al. Fabrication of acid-resistant imprinted layer on magnetic nanomaterials for selective extraction of chlorogenic acid in Honeysuckle . | ANALYTICA CHIMICA ACTA , 2021 , 1161 . |
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Abstract ：
Biomimetic cell membrane-coated nanoparticles have been broadly applied because of their superior biochemical properties. The right-side-out cell membrane coating manner provides nanoparticles with an immune-evasive stealth function in vivo. However, this acts as a drag for drug discovery when the drug targets are the intracellular domain of transmembrane receptors. Herein, inside-out-oriented cell membrane-coated nanoparticles were prepared for screening tyrosine kinase inhibitors, which specifically interacted with the intracellular kinase domain of the epidermal growth factor receptor. Biotinylated human lung adenocarcinoma epithelial cell membranes specifically interacted with streptavidin-immobilized Fe3O4 magnetic nanoparticles and then formed inside-out-oriented cell membrane-coated magnetic nanoparticles (IOCMMNPs). The cell membrane orientation of the IOCMMNPs was successfully confirmed by immunogold electron microscopy, fluorescently labeled confocal microscopy, sialic acid quantification assay, and the adsorption capacity assay. Moreover, IOCMMNPs possessed satisfactory binding capacity, selectivity, and high sensitivity (limit of detection = 0.4 x 10(-3) mu g mL(-1)). Ultimately, IOCMMNPs successfully targeted two main compounds from Strychnos nux-vomica whose potential antitumor activities were further validated by pharmacological studies. The application of the inside-out cell membrane coating strategy further enhances the drug screening efficiency and broadens the insight and methodologies for drug lead discovery. This inside-out cell membrane coating concept also provides a method for the future development of engineered cell membrane-coated nanotechnology.
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| GB/T 7714 | Bu, Yusi , Zhang, Xiaolin , Zhu, Aihong et al. Inside-Out-Oriented Cell Membrane Biomimetic Magnetic Nanoparticles for High-Performance Drug Lead Discovery [J]. | ANALYTICAL CHEMISTRY , 2021 , 93 (22) : 7898-7907 . |
| MLA | Bu, Yusi et al. "Inside-Out-Oriented Cell Membrane Biomimetic Magnetic Nanoparticles for High-Performance Drug Lead Discovery" . | ANALYTICAL CHEMISTRY 93 . 22 (2021) : 7898-7907 . |
| APA | Bu, Yusi , Zhang, Xiaolin , Zhu, Aihong , Li, Linhao , Xie, Xiaoyu , Wang, Sicen . Inside-Out-Oriented Cell Membrane Biomimetic Magnetic Nanoparticles for High-Performance Drug Lead Discovery . | ANALYTICAL CHEMISTRY , 2021 , 93 (22) , 7898-7907 . |
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