The　Nrf2　pathway　and　autophagy　are　abnormally　activated　in　response　to　cellular　stress　in　various　types　of　human　cancers.　We　found　that　the　protein　levels　of　Beclin1　were　significantly　lower　in　NSCLC　tissue　specimens　than　in　paired　normal　tissue,　while　the　expressions　of　Nrf2　protein　were　increased.　And　the　reduced　expression　of　Beclin1　protein　level　was　found　to　be　significantly　associated　with　more　advanced　TNM　stage　(P　=　0.035),　lymph　node　metastasis　(P　=　0.017)　and　distant　metastasis　(P　=　0.005)　while　the　increased　expression　of　Nrf2　protein　was　associated　with　larger　tumor　size　(P　=　0.032),　more　advanced　TNM　stage　(P　=　0.011),　lymph　node　metastasis　(P　=　0.045)　and　distant　metastasis　(P　=　0.013).　We　also　found　that　there　was　a　strong　inverse　relationship　between　Beclin1　and　Nrf2　expression　in　the　NSCLC　tissues(r=-0.260,　P=0.005).　Univariate　analysis　revealed　that　the　tumor　size,　histological　grade,　TNM　stage,　Lymph　node　metastasis,　distant　metastasis,　Beclin1,　Nrf2,　and　Beclin1-/Nrf2+　expression　were　all　significant　prognostic　indicators.　Multivariate　analysis　showed　that　distant　metastasis,　Beclin1,　Nrf2,　and　Beclin1-/Nrf2+　expression　were　risk　factors　for　poor　survival　of　NSCLC　patients.　This　study　indicated　that　the　abnormal　expression　of　Beclin1　and　Nrf2　contributed　to　the　progression　of　NSCLC.