Hydroxytyrosol　(HT)　is　a　natural　polyphenol　antioxidant　that　exists　in　olive　oil.　In　the　study　of　multifunctional　hypolipidemic　of　nicotinic　derivatives,　we　found　that　hydroxytyrosol　nicotinate　(HT-N)　incorporation　of　niacin　with　HT　displayed　alpha-glucosidase　inhibitory　activities　in　vitro,　such　as　yeast　alpha-glucosidase　(IC50　=　117.72　mu　M)　and　rat　intestinal　alpha-glucosidases　maltase　(IC50　=　31.86　mu　M)　and　sucrase　(IC50　=　22.99　mu　M),　and　had　a　good　control　of　postprandial　blood　glucose　(PBG).　HT-N　shown　significantly　hypoglycemic　action　by　16.9%　and　protection　of　pancreatic　tissue　in　type　2　diabetic　mellitus　(T2DM)　mouse　model.　HT-N　also　shown　a　potent　antioxidant　activity　and　property　of　anti-glycation　in　vitro,　which　were　benefit　for　ameliorating　diabetic　complications.　Moreover,　HT-N　exhibited　much　significant　hypolipidemia,　lowering　plasma　triglyceride　(TG),　total　cholesterol　(TC),　and　malonaldehyde　(MDA)　by　34.6%,　45.8%　and　32.1%　respectively,　in　hyperlipidemic　mice　induced　by　Triton　WR　1339.　The　results　indicated　that　HT-N　has　hypolipidemic,　hypoglycemic　and　antioxidant　actions.　All　these　properties　could　be　conducive　to　amelioration　of　oxidative　stress,　hyperlipidemia,　and　diabetes　that　HT-N　may　serve　as　a　multifunctional　potential　therapeutic　strategy　in　diabetic　patients　with　hyperlipidemia.