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Abstract：
Rodent models of obesity induced by consuming high-fat diet (HFD) are characterized by inflammation both in peripheral tissues and in hypothalamic areas critical for energy homeostasis. Here we report that unlike inflammation in peripheral tissues, which develops as a consequence of obesity, hypothalamic inflammatory signaling was evident in both rats and mice within 1 to 3 days of HFD onset, prior to substantial weight gain. Furthermore, both reactive gliosis and markers suggestive of neuron injury were evident in the hypothalamic arcuate nucleus of rats and mice within the first week of HFD feeding. Although these responses temporarily subsided, suggesting that neuroprotective mechanisms may initially limit the damage, with continued HFD feeding, inflammation and gliosis returned permanently to the mediobasal hypothalamus. Consistent with these data in rodents, we found evidence of increased gliosis in the mediobasal hypothalamus of obese humans, as assessed by MRI. These findings collectively suggest that, in both humans and rodent models, obesity is associated with neuronal injury in a brain area crucial for body weight control.
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JOURNAL OF CLINICAL INVESTIGATION
ISSN： 0021-9738
Year： 2012
Issue： 1
Volume： 122
Page： 153-162
1 2 . 8 1 2
JCR@2012
1 4 . 8 0 8
JCR@2020
ESI Discipline： CLINICAL MEDICINE;
ESI HC Threshold：222
JCR Journal Grade：1
CAS Journal Grade：1
Cited Count：
WoS CC Cited Count： 1112
SCOPUS Cited Count： 965
ESI Highly Cited Papers on the List： 47 Unfold All
WanFang Cited Count：
Chinese Cited Count：
30 Days PV： 0
