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Flow　injection　chemiluminescence　was　a　new　kind　of　method　for　micro　and　trace　analysis.　This　method　has　many　virtues　including　simple　instrument,　easy　operation,　high　sensitivity,　wide　linear　range　and　easy　automation.　Now,　it　was　widely　used　in　many　sciences　such　as　geology,　environment,　science,　molecular　biology,　clinical　analysis,　pharmaceutical　analysis　and　et,　al.　However,　the　establishment　of　a　high-performance　and　stable　chemiluminescence　method　and　the　application　of　this　new　method　in　pharmaceutical　analysis　were　still　the　hot　topic　of　the　research.A　new　flow　injection　chemiluminescence　method　in　KMnO4-Na2SO3　system　was　established　in　this　thesis.　Moreover,　this　method　was　used　to　analyze　the　NSAIDs,　paracetamol,　tramadol　hydrochloride,　carbamazepine,　corticosteroids,　et　al.　in　pharmaceutical　preparations.　And　the　mechanism　of　this　chemiluminescence　system　was　presented　according　to　the　previous　publication.　The　main　contents　of　this　thesis　were　listed　as　follows:1.　A　new　flow　injection　chemiluminescence　method　in　KMnO4-Na2SO3　system　was　established　by　using　Ibuprofen　as　the　index.　Moreover,　the　effect　of　flow　procedure,　the　voltage　of　PMT,　sample　volume,　the　length　of　mixing　tube,　the　flow　rate　and　the　concentration　of　the　reaction　materials　on　the　chemiluminescence　signals　were　investigated.　The　results　indicated　that　the　detection　limit　of　this　method　was　3.0ng/mL　and　the　linear　range　was　1.0×10-8-1.0×10-5g/mL,　indicating　that　this　method　could　be　used　in　the　analysis　of　Ibuprofen　and　other　pharmaceutical　analysis.2.　Ibuprofen,　Fenbufen　and　Naproxen　were　determined　in　pharmaceutical　preparations　by　this　new　method.　The　results　indicated　that　the　linear　ranges　were1.0×10-8-1.0×10-5g/mL，1.0×10-8-1.0×10-5g/mL，1.0×10-9-1.0×10-6g/mL,　respectively.　The　limits　of　detection　were　3.0ng/mL,　5.0ng/mL　and　0.5ng/mL.　Relative　standard　deviations　of　the　11　parallel　determinations　were　3.8%,　2.6%　and　3.2%,　respectively.3.　Paracetamol　was　analyzed　in　pharmaceutical　preparations　by　this　new　method.　The　results　showed　that　the　linear　range　of　this　method　was　1.0×10-8-1.0×10-5g/mL　with　the　detection　limit　of　2.0ng/mL.　Relative　standard　deviations　of　the　11　parallel　determinations　was　2.6%.4.　Tramadol　was　determined　in　pharmaceutical　preparations　by　this　new　method.　The　results　showed　that　the　CL　intensity　of　tramadol　was　linear　over　the　range　of　1.0×10-8-1.0×10-6g/mL　and　the　limit　of　detection　was　3.2ng/mL.　Relative　standard　deviations　of　the　11　parallel　determinations　was　1.6%.5.　Carbamazepine　was　determined　by　this　new　method.　The　results　indicated　that　the　CL　intensity　was　linear　over　the　concentration　of　carbamazepine　ranging　from　1.0×10-9　to　1.0×10-6g/mL　with　the　detection　limit　as　low　as　0.2ng/mL.　Relative　standard　deviations　of　the　11　parallel　determinations　were　0.9%.6.　Hydrocortisone,　prednisone　acetate,　and　sodium　phosphate　dexamethasone　were　analyzed　in　their　pharmaceutical　preparations　by　this　new　method.　The　results　indicated　that　the　linear　ranges　were　1.0×10-9-1.0×10-6g/mL，5.0×10-9-1.0×10-5g/mL，1.0×10-8-1.0×10-5g/mL,　respectively.　The　limits　of　detection　were　0.4ng/mL,　1.0ng/mL,　5.0ng/mL.　Relative　standard　deviations　of　the　11　parallel　determinations　were　2.8%,　1.2%　and　2.6%,　respectively.7.　It　was　postulated　that　the　chemiluminescence　of　the　KMnO4-Na2SO3　system　arises　from　excited　sulphur　dioxide　(SO2*)　as　the　emitter　during　the　reaction.　We　presumed　that　KMnO4　could　react　with　medicine　to　produce　a　complex　oxygen　molecule　of　single　state,　such　as　1O2(1Δg).　It　could　transform　Na2SO3　into　S2O62-　in　acid　medium.　And　then,　S2O62-　produced　SO42-　and　SO2*.　SO2*　released　CL　at　last.　Therefore,　we　assumed　that　the　medicine　could　react　with　KMnO4　and　produced　CL　by　the　transformation　of　Na2SO3.　A　new　flow　injection　chemiluminescence　method　in　KMnO4-Na2SO3　system　was　established　in　this　thesis.　This　method　has　many　virtues　including　high　sensitivity,　wide　linear　range　and　easy　automation.　It　was　used　to　determine　the　NSAIDs,　paracetamol,　tramadol　hydrochloride,　carbamazepine,　corticosteroids,　et　al.　And　the　result　showed　that　this　method　could　be　used　in　other　pharmaceutical　analysis.

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