Cardiovascular　diseases　(CVDs)　are　the　leading　cause　of　death　globally.　Most　of　them　are　preventable　and　treatable,　which　largely　depend　on　timely　and　effective　diagnosis　and　interventions.　Owing　to　the　rapid　growth　of　nanotechnology　and　microfluidics,　many　portable　devices　are　developed　for　monitoring　of　CVDs　at　the　point-of-care　(POC).　In　addition,　smartphone,　as　a　popular　and　versatile　handheld　tool,　has　been　used　not　only　as　a　reader　for　microfluidic　assays,　but　also　as　an　analyzer　for　physiological　indexes.　In　this　review,　we　provide　a　comprehensive　overview　of　the　current　status　and　potential　development　of　POC　diagnostics　for　CVDs,　introduce　some　commercial　POC　devices　and　developed　prototypes,　and　present　the　advances　in　the　monitoring　of　CVDs　based　on　the　smartphone　independently　or　combined　with　other　devices.　We　envision　that　an　integrated　system　based　on　smartphone　that　enables　blood　testing,　disease　examination,　and　imaging　will　be　the　focus　of　future　POC　research.　©　2016,　Science　Press.　All　right　reserved.