To　explore　the　effects　of　T-2　toxin　and　it＇s　synergy　with　low　selenium　on　lipid　peroxidation　in　rats＇　brain.Early　weaning　male　SD　(Sprague-Dawley)　rats　were　randomly　divided　into　normal　group　and　low-selenium　model　group　by　weight　after　1　week　for　adaptive　feeding,　and　respectively　fed　normal　diet　and　low-selenium　diet.　After　the　low　Se　model　was　succeed,　the　normal　group　were　randomly　divided　into　control　group,　low　T-2　group,　high　T-2　group,　the　model　group　were　randomly　divided　into　low　Se　group,　low　Se　+　low　T-2　group,　low　Se　+　high　T-2　group.　Then　give　T-2　toxin　to　the　low　T-2　group,　low　Se　+　low　T-2　group　at　the　dose　of　0.1　mg/(kg　x　d),　and　high　T-2　group,　low　Se　+　high　T-2　group　at　the　dose　of　0.2　(kg　x　d),　intragastric　administration　for　4　weeks.　We　take　the　brain　sample,　observed　the　morphological　changes　of　brain　tissue　after　HE　staining,　measured　the　content　of　MDA　and　the　activity　of　GSH-Px　to　observe　the　T-2　toxin＇　effect　of　antioxidant　on　rat　brain.The　activity　of　rats＇　brain　GSH-Px　in　all　low　Se　groups　were　lower　than　the　control　group　(P　＜　0.05).　The　content　of　rats＇　brain　MDA　in　all　experimental　group　were　higher　than　the　control　group　(P　＜　0.05).　In　all　experimental　group,　the　structure,　the　neurons,　the　nuclei　of　rats＇　brain　tissue　have　varying　degrees　of　damage　and　destruction.The　single　factor　of　T-2　toxin　can　cause　lipid　peroxidation　in　brain,　lower　the　activity　of　GSH-Px　and　higher　the　lever　of　MDA.　The　single　factor　of　low　Se　can　induce　lipid　peroxidation　in　rats＇　brain,　lower　the　activity　of　GSH-Px,　higher　the　level　of　MDA,　With　the　condition　of　low　Se,　the　effect　of　T-2　toxin　on　lipid　peroxidation　in　rats＇　brain　was　more　obviously　than　the　single　factor.　There　have　synergistic　effect　T-2　toxin　with　low　Se.