Astrocyte　elevated　gene-1　(AEG-1)　is　associated　with　tumor　genesis　and　progression　in　a　variety　of　human　cancers.　This　study　aimed　to　explore　the　significance　of　AEG-1　in　glioma　and　investigate　whether　it　correlated　with　radioresistance　of　glioma　cells.　Immunohistochemical　staining　showed　that　the　intensity　of　AEG-1,　CD133　and　PPP6c　protein　expression　in　glioma　tissues　increased　significantly,　mainly　in　the　cytoplasm.　The　expression　rate　of　AEG-1,　CD133　and　PPP6c　were　85.9%　(67/78),　60.3%　(47/78)　and　65.8%　(51/78),　respectively.　AEG-1　expression　was　correlated　with　age　(r = 0.227,　P = 0.045),　clinical　stage　(r = 0.491,　P＜0.001)　and　clinical　grade　(r = 0.450,　P＜0.001).　No　correlation　was　found　between　AEG-1　expression　and　other　clinicopathologic　parameters　(P＞0.05).　The　expression　of　AEG-1　was　positively　correlated　with　the　expression　of　CD133　(r = 0.240,　P　 = 　0.035)　and　PPP6c　(r = 　0.250,　P　 = 　0.027).　In　addition,　retrieved　data　on　TCGA　implied　co-occurrence　of　genomic　alterations　of　AEG-1　and　PPP6c　in　glioblastoma.　Our　findings　indicate　that　AEG-1　is　positively　correlated　with　CD133　and　AEG-1　expression.　It　may　play　an　important　role　in　the　progression　of　glioma　and　may　serve　as　potential　novel　marker　of　chemoresistance　and　radioresistance.