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Author:

Guo Jia (Guo Jia.) | Chen Xin (Chen Xin.) | Xi Ruxing (Xi Ruxing.) | Chang Yuwei (Chang Yuwei.) | Zhang Xuanwei (Zhang Xuanwei.) | Zhang Xiaozhi (Zhang Xiaozhi.)

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PubMed Scopus

Abstract:

Astrocyte elevated gene-1 (AEG-1) is associated with tumor genesis and progression in a variety of human cancers. This study aimed to explore the significance of AEG-1 in glioma and investigate whether it correlated with radioresistance of glioma cells. Immunohistochemical staining showed that the intensity of AEG-1, CD133 and PPP6c protein expression in glioma tissues increased significantly, mainly in the cytoplasm. The expression rate of AEG-1, CD133 and PPP6c were 85.9% (67/78), 60.3% (47/78) and 65.8% (51/78), respectively. AEG-1 expression was correlated with age (r = 0.227, P = 0.045), clinical stage (r = 0.491, P<0.001) and clinical grade (r = 0.450, P<0.001). No correlation was found between AEG-1 expression and other clinicopathologic parameters (P>0.05). The expression of AEG-1 was positively correlated with the expression of CD133 (r = 0.240, P  =  0.035) and PPP6c (r =  0.250, P  =  0.027). In addition, retrieved data on TCGA implied co-occurrence of genomic alterations of AEG-1 and PPP6c in glioblastoma. Our findings indicate that AEG-1 is positively correlated with CD133 and AEG-1 expression. It may play an important role in the progression of glioma and may serve as potential novel marker of chemoresistance and radioresistance.

Keyword:

immunohistochemistry radioresistance AEG-1 glioma

Author Community:

  • [ 1 ] [Guo Jia;Chen Xin;Xi Ruxing;Chang Yuwei;Zhang Xuanwei;Zhang Xiaozhi]Department of Radiotherapy, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.

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Source :

Journal of biomedical research

ISSN: 1674-8301

Year: 2014

Issue: 5

Volume: 28

Page: 388-95

ESI Discipline: MULTIDISCIPLINARY;

ESI HC Threshold:202

Cited Count:

WoS CC Cited Count: 0

SCOPUS Cited Count: 7

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 3

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